DNMT3B Monoclonal Antibody
- SKU:
- CAB22658
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | DNMT3B Monoclonal Antibody |
| Product Code: | CAB22658 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57702 |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IP, ChIP, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000, ChIP 1:50-1:100 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Mouse testis, F9 |
| Cellular Location: | Nucleus |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1- 410 of human DNMT3B (NP_612564.1) |
| Sequence: | MKGDT RHLNG EEDAG GREDS ILVNG ACSDQ SSDSP PILEA IRTPE IRGRR SSSRL SKREV SSLLS YTQDL TGDGD GEDGD GSDTP VMPKL FRETR TRSES PAVRT RNNNS VSSRE RHRPS PRSTR GRQGR NHVDE SPVEF PATRS LRRRA TASAG TPWPS PPSSY LTIDL TDDTE DTHGT PQSSS TPYAR LAQDS QQGGM ESPQV EADSG DGDSS EYQDG KEFGI GDLVW GKIKG FSWWP AMVVS WKATS KRQAM SGMRW VQWFG DGKFS EVSAD KLVAL GLFSQ HFNLA TFNKL VSYRK AMYHA LEKAR VRAGK TFPSS PGDSL EDQLK PMLEW AHGGF KPTGI EGLKP NNTQP VVNKS KVRRA GSRKL ESRKY ENKTR RRTAD DSATS DYCPA PKRLK TNCYN NGKDR |
| Synonyms: | ICF, ICF1, FSHD4, M.HsaIIIB |
| Calculated MW: | 96kDa |
| Observed MW: | 100kDa |
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