DNMT1 Polyclonal Antibody (CAB21378)
- SKU:
- CAB21378
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | DNMT1 Polyclonal Antibody |
| Product Code: | CAB21378 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, IP, ChIP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200, IP 1:500-1:1000, ChIP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1417-1616 of human DNMT1 (NP_001370.1). |
| Sequence: | MSALV AARMR HIPLA PGSDW RDLPN IEVRL SDGTM ARKLR YTHHD RKNGR SSSGA LRGVC SCVEA GKACD PAARQ FNTLI PWCLP HTGNR HNHWA GLYGR LEWDG FFSTT VTNPE PMGKQ GRVLH PEQHR VVSVR ECARS QGFPD TYRLF GNILD KHRQV GNAVP PPLAK AIGLE IKLCM LAKAR ESASA KIKEE EAAKD |
| Synonyms: | AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, m.HsaI |
| Calculated MW: | 183kDa |
| Observed MW: | Refer to figures |
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