DNMT1 Monoclonal Antibody
- SKU:
- CAB22455
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | DNMT1 Monoclonal Antibody |
| Product Code: | CAB22455 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51345 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:500-1:1000, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, Jurkat, Mouse liver, Mouse testis, Rat brain |
| Cellular Location: | Nucleus |
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DNMT1 (NP_001370.1). |
| Sequence: | MPART APARV PTLAV PAISL PDDVR RRLKD LERDS LTEKE CVKEK LNLLH EFLQT EIKNQ LCDLE TKLRK EELSE EGYLA KVKSL LNKDL SLENG AHAYN |
| Synonyms: | AIM, DNMT, MCMT, CXXC9, HSN1E, ADCADN, m.HsaI |
| Calculated MW: | 183kDa |
| Observed MW: | 200kDa |
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