DNM1L Polyclonal Antibody
- SKU:
- CAB21311
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | DNM1L Polyclonal Antibody |
| Product Code: | CAB21311 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Golgi apparatus, Membrane, Mitochondrion outer membrane, Peripheral membrane protein, Peroxisome, clathrin-coated pit, cytosol, secretory vesicle, synaptic vesicle membrane |
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 437-736 of human DNM1L (NP_036192.2). |
| Sequence: | EEMQR IIQHC SNYST QELLR FPKLH DAIVE VVTCL LRKRL PVTNE MVHNL VAIEL AYINT KHPDF ADACG LMNNN IEEQR RNRLA RELPS AVSRD KSSKV PSALA PASQE PSPAA SAEAD GKLIQ DSRRE TKNVA SGGGG VGDGV QEPTT GNWRG MLKTS KAEEL LAEEK SKPIP IMPAS PQKGH AVNLL DVPVP VARKL SAREQ RDCEV IERLI KSYFL IVRKN IQDSV PKAVM HFLVN HVKDT LQSEL VGQLY KSSLL DDLLT ESEDM AQRRK EAADM LKALQ GASQI IAEIR ETHLW |
| Synonyms: | DLP1, DRP1, DVLP, EMPF, OPA5, EMPF1, DYMPLE, HDYNIV |
| Calculated MW: | 82kDa |
| Observed MW: | Refer to figures |
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