DNAJC6 Antibody (PACO26273)
- SKU:
- PACO26273
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DNAJC6 Antibody (PACO26273) |
| Antibody SKU: | PACO26273 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Putative tyrosine-protein phosphatase auxilin protein (201-500AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO26273 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO26273 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human skin tissue using PACO26273 at dilution of 1:100. |
| Background: | Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons. |
| Synonyms: | Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6), DNAJC6, KIAA0473 |
| UniProt Protein Function: | DNAJC6: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); Chaperone; EC 3.1.3.48Chromosomal Location of Human Ortholog: 1p31.3Cellular Component: cytosolDisease: Parkinson Disease 19, Juvenile-onset |
| UniProt Protein Details: | |
| NCBI Summary: | DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O75061 |
| NCBI GenInfo Identifier: | 109818722 |
| NCBI Gene ID: | 9829 |
| NCBI Accession: | O75061.3 |
| UniProt Secondary Accession: | O75061,Q32M66, Q4G0K1, Q5T614, Q5T615, B7Z3V8, D3DQ65 D3DQ66 |
| UniProt Related Accession: | O75061 |
| Molecular Weight: | 98,649 Da |
| NCBI Full Name: | Putative tyrosine-protein phosphatase auxilin |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C6 |
| NCBI Official Symbol: | DNAJC6 |
| NCBI Official Synonym Symbols: | DJC6; PARK19 |
| NCBI Protein Information: | putative tyrosine-protein phosphatase auxilin |
| UniProt Protein Name: | Putative tyrosine-protein phosphatase auxilin |
| UniProt Synonym Protein Names: | DnaJ homolog subfamily C member 6 |
| Protein Family: | Putative tyrosine-protein phosphatase auxilin |
| UniProt Gene Name: | DNAJC6 |
| UniProt Entry Name: | AUXI_HUMAN |
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