DNAJC3 Antibody (PACO46506)
- SKU:
- PACO46506
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DNAJC3 Antibody (PACO46506) |
| Antibody SKU: | PACO46506 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DnaJ homolog subfamily C member 3 protein (277-496AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO46506 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO46506 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human melanoma using PACO46506 at dilution of 1:100. |
| Background: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-α at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid, starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| Synonyms: | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58), DNAJC3, P58IPK PRKRI |
| UniProt Protein Function: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q13217 |
| NCBI GenInfo Identifier: | 5453980 |
| NCBI Gene ID: | 5611 |
| NCBI Accession: | NP_006251.1 |
| UniProt Secondary Accession: | Q13217,Q86WT9, Q8N4N2 |
| UniProt Related Accession: | Q13217 |
| Molecular Weight: | 55 |
| NCBI Full Name: | dnaJ homolog subfamily C member 3 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C3 |
| NCBI Official Symbol: | DNAJC3 |
| NCBI Official Synonym Symbols: | P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK |
| NCBI Protein Information: | dnaJ homolog subfamily C member 3 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 3 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58 |
| Protein Family: | |
| UniProt Gene Name: | DNAJC3 |
| UniProt Entry Name: |
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