DNAJC3 Antibody (PACO14816)
- SKU:
- PACO14816
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DNAJC3 Antibody (PACO14816) |
| Antibody SKU: | PACO14816 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DNAJC3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14816(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14816(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). |
| Synonyms: | DnaJ (Hsp40) homolog, subfamily C, member 3 |
| UniProt Protein Function: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010] |
| UniProt Code: | Q13217 |
| NCBI GenInfo Identifier: | 5453980 |
| NCBI Gene ID: | 5611 |
| NCBI Accession: | NP_006251.1 |
| UniProt Secondary Accession: | Q13217,Q86WT9, Q8N4N2 |
| UniProt Related Accession: | Q13217 |
| Molecular Weight: | 55 |
| NCBI Full Name: | dnaJ homolog subfamily C member 3 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C3 |
| NCBI Official Symbol: | DNAJC3 |
| NCBI Official Synonym Symbols: | P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK |
| NCBI Protein Information: | dnaJ homolog subfamily C member 3 |
| UniProt Protein Name: | DnaJ homolog subfamily C member 3 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58 |
| Protein Family: | |
| UniProt Gene Name: | DNAJC3 |
| UniProt Entry Name: |
Related Products
Human DNAJC30 Recombinant Protein (RPES4053)
system_update_altDatasheetHuman DNAJC30 Recombinant Protein NAJC30 is a member of the DNAJ molecular chaperone homology domain-containing protein family. DNAJC30 gene is deleted in williams syn
OSTN Antibody
Overview Product Name:OSTN AntibodyProduct Code:PACO64881Size:50µLTarget Names:OSTNSpecies Reactivity:HumanHost