Description
Antibody Name: | DNAJC3 Antibody (PACO14815) |
Antibody SKU: | PACO14815 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein of human DNAJC3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14815(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14815(DNAJC3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). |
Synonyms: | DnaJ (Hsp40) homolog, subfamily C, member 3 |
UniProt Protein Function: | Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010] |
UniProt Code: | Q13217 |
NCBI GenInfo Identifier: | 5453980 |
NCBI Gene ID: | 5611 |
NCBI Accession: | NP_006251.1 |
UniProt Secondary Accession: | Q13217,Q86WT9, Q8N4N2 |
UniProt Related Accession: | Q13217 |
Molecular Weight: | 55 |
NCBI Full Name: | dnaJ homolog subfamily C member 3 |
NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C3 |
NCBI Official Symbol: | DNAJC3 |
NCBI Official Synonym Symbols: | P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK |
NCBI Protein Information: | dnaJ homolog subfamily C member 3 |
UniProt Protein Name: | DnaJ homolog subfamily C member 3 |
UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 6; ER-resident protein ERdj6; ERdj6; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58 |
Protein Family: | |
UniProt Gene Name: | DNAJC3 |
UniProt Entry Name: |