Description
Antibody Name: | DNAI2 Antibody (PACO05041) |
Antibody SKU: | PACO05041 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthesized peptide derived from the N-terminal region of human Dynein IC2. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | DNAI2; Dynein intermediate chain 2; axonemal; Axonemal dynein intermediate chain 2 |
UniProt Protein Function: | DNAI2: Part of the dynein complex of respiratory cilia. Defects in DNAI2 are the cause of primary ciliary dyskinesia type 9 (CILD9). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Belongs to the dynein intermediate chain family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motor; Motility/polarity/chemotaxis; Microtubule-bindingChromosomal Location of Human Ortholog: 17q25Cellular Component: microtubule; axonemal dynein complex; axonemeMolecular Function: protein binding; microtubule motor activityBiological Process: metabolic process; cilium biogenesisDisease: Ciliary Dyskinesia, Primary, 9 |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | Q9GZS0 |
NCBI GenInfo Identifier: | 289802997 |
NCBI Gene ID: | 64446 |
NCBI Accession: | NP_001166281.1 |
UniProt Secondary Accession: | Q9GZS0 |
UniProt Related Accession: | Q9GZS0 |
Molecular Weight: | ~ 73kDa |
NCBI Full Name: | dynein intermediate chain 2, axonemal isoform 2 |
NCBI Synonym Full Names: | dynein axonemal intermediate chain 2 |
NCBI Official Symbol: | DNAI2 |
NCBI Official Synonym Symbols: | DIC2; CILD9 |
NCBI Protein Information: | dynein intermediate chain 2, axonemal |
UniProt Protein Name: | Dynein intermediate chain 2, axonemal |
UniProt Synonym Protein Names: | Axonemal dynein intermediate chain 2 |
Protein Family: | |
UniProt Gene Name: | DNAI2 |
UniProt Entry Name: | DNAI2_HUMAN |