DNAH12 Antibody (PACO50674)
- SKU:
- PACO50674
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DNAH12 Antibody (PACO50674) |
| Antibody SKU: | PACO50674 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Dynein heavy chain 12, axonemal protein (2423-2632AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO50674 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: DNAH12 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa. |
| Background: | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). |
| Synonyms: | Dynein heavy chain 12, axonemal (Axonemal β dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein heavy chain 7-like, axonemal) (Dynein heavy chain domain-containing protein 2), DNAH12, DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 |
| UniProt Protein Function: | DNAHC12: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Belongs to the dynein heavy chain family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 3p14.3 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6ZR08 |
| NCBI GenInfo Identifier: | 89274173 |
| NCBI Gene ID: | 201625 |
| NCBI Accession: | NP_940966.2 |
| UniProt Secondary Accession: | Q6ZR08,Q6ZTR8, Q8N7R9, Q8WXK2, Q92816, A6NGI2 |
| UniProt Related Accession: | Q6ZR08 |
| Molecular Weight: | 125,223 Da |
| NCBI Full Name: | dynein heavy chain 12, axonemal isoform 2 |
| NCBI Synonym Full Names: | dynein axonemal heavy chain 12 |
| NCBI Official Symbol: | DNAH12 |
| NCBI Official Synonym Symbols: | DHC3; DLP3; HL19; DLP12; DNHD2; HDHC3; HL-19; DNAH7L; DNAHC3; DNAH12L; DNAHC12 |
| NCBI Protein Information: | dynein heavy chain 12, axonemal |
| UniProt Protein Name: | Dynein heavy chain 12, axonemal |
| UniProt Synonym Protein Names: | Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 7-like protein; Ciliary dynein heavy chain 12; Dynein heavy chain 7-like, axonemal; Dynein heavy chain domain-containing protein 2 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DNAH12 |
| UniProt Entry Name: | DYH12_HUMAN |
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