DNA Ligase III/LIG3 Monoclonal Antibody
- SKU:
- CAB22136
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | DNA Ligase III/LIG3 Monoclonal Antibody |
| Product Code: | CAB22136 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55533 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-87MG, Jurkat, 293F, Mouse testis, Rat testis |
| Cellular Location: | cytoplasm, mitochondrion, nucleoplasm, nucleus |
| Customer Validation: | WB(Rattus norvegicus) |
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DNA Ligase III/LIG3 (NP_039269.2). |
| Sequence: | IASRC TANDL KCIIR LIKHD LKMNS GAKHV LDALD PNAYE AFKAS RNLQD VVERV LHNAQ EVEKE PGQRR ALSVQ ASLMT PVQPM LAEAC KSVEY AMKKC P |
| Synonyms: | LIG2, MTDPS20, LIG3alpha |
| Calculated MW: | 113kDa |
| Observed MW: | 96kDa(DNA Ligase III β); 103kDa(DNA Ligase III α) |
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