DMXL2 Antibody (PACO46806)
- SKU:
- PACO46806
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DMXL2 Antibody (PACO46806) |
| Antibody SKU: | PACO46806 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DmX-like protein 2 protein (2471-2657AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO46806 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO46806 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). |
| Synonyms: | DmX-like protein 2 (Rabconnectin-3), DMXL2, KIAA0856 |
| UniProt Protein Function: | RC3: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffold; Vesicle; Membrane protein, peripheralChromosomal Location of Human Ortholog: 15q21.2Cellular Component: extracellular space; synaptic vesicle; synaptic vesicle membrane; cell junctionMolecular Function: Rab GTPase bindingDisease: Polyendocrine-polyneuropathy Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q8TDJ6 |
| NCBI GenInfo Identifier: | 291621657 |
| NCBI Gene ID: | 23312 |
| NCBI Accession: | NP_001167587.1 |
| UniProt Secondary Accession: | Q8TDJ6 |
| UniProt Related Accession: | Q8TDJ6 |
| Molecular Weight: | 340 kDa |
| NCBI Full Name: | dmX-like protein 2 isoform 1 |
| NCBI Synonym Full Names: | Dmx like 2 |
| NCBI Official Symbol: | DMXL2 |
| NCBI Official Synonym Symbols: | RC3; PEPNS; DFNA71 |
| NCBI Protein Information: | dmX-like protein 2 |
| UniProt Protein Name: | DmX-like protein 2 |
| UniProt Synonym Protein Names: | Rabconnectin-3 |
| Protein Family: | DmX-like protein |
| UniProt Gene Name: | DMXL2 |
| UniProt Entry Name: | DMXL2_HUMAN |
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