Antibody Name:	Dio3 Antibody (PACO34546)
Antibody SKU:	PACO34546
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rat
Immunogen:	Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.

Synonyms:

Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase), Dio3, Itdi3 Txdi3

UniProt Protein Function:	DIO3: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Belongs to the iodothyronine deiodinase family.
UniProt Protein Details:	Protein type:EC 1.97.1.11; Oxidoreductase; Membrane protein, integral Cellular Component: endosome membrane; integral to membrane; plasma membrane Molecular Function:thyroxine 5'-deiodinase activity; thyroxine 5-deiodinase activity Biological Process: hormone biosynthetic process; positive regulation of multicellular organism growth; response to hypoxia; thyroid hormone catabolic process; thyroid hormone metabolic process
NCBI Summary:	The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. It contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
UniProt Code:	P49897
NCBI GenInfo Identifier:	255982585
NCBI Gene ID:	29475
NCBI Accession:	NP_058906.3
UniProt Related Accession:	P49897
Molecular Weight:	29.5 kDa
NCBI Full Name:	thyroxine 5-deiodinase
NCBI Synonym Full Names:	deiodinase, iodothyronine, type III
NCBI Official Symbol:	Dio3
NCBI Official Synonym Symbols:	5DIII; DIOIII
NCBI Protein Information:	thyroxine 5-deiodinase
UniProt Protein Name:	Thyroxine 5-deiodinase
UniProt Synonym Protein Names:	5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase
Protein Family:	Thyroxine 5-deiodinase
UniProt Gene Name:	Dio3
UniProt Entry Name:	IOD3_RAT