Name: DIO1 Antibody (PACO34530)
SKU: PACO34530
Availability: OutOfStock

Antibody Name:	DIO1 Antibody (PACO34530)
Antibody SKU:	PACO34530
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Human
Immunogen:	Recombinant Human Type I iodothyronine deiodinase protein (34-249AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:	Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Synonyms:	Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase), DIO1, ITDI1 TXDI1

UniProt Protein Function:	DIO1: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. Belongs to the iodothyronine deiodinase family. 9 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; EC 1.97.1.10; Oxidoreductase Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: plasma membrane Molecular Function:selenium binding; thyroxine 5'-deiodinase activity Biological Process: thyroid hormone generation
NCBI Summary:	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
UniProt Code:	P49895
NCBI GenInfo Identifier:	182702125
NCBI Gene ID:	1733
NCBI Accession:	P49895.3
UniProt Secondary Accession:	P49895,Q1RN02, Q3KNP8, Q6Q4C1, Q6Q4C2, Q6Q4C3, Q6Q4C4 Q6Q4C5, Q6Q4C6, Q6Q4C7, Q6Q4C9, Q8WWC6,
UniProt Related Accession:	P49895
Molecular Weight:	9,774 Da
NCBI Full Name:	Type I iodothyronine deiodinase
NCBI Synonym Full Names:	deiodinase, iodothyronine type I
NCBI Official Symbol:	DIO1
NCBI Official Synonym Symbols:	5DI; TXDI1
NCBI Protein Information:	type I iodothyronine deiodinase
UniProt Protein Name:	Type I iodothyronine deiodinase
UniProt Synonym Protein Names:	5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase
Protein Family:	Type I iodothyronine deiodinase
UniProt Gene Name:	DIO1
UniProt Entry Name:	IOD1_HUMAN