DEUP1 Antibody (PACO60649)
- SKU:
- PACO60649
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DEUP1 Antibody (PACO60649) |
| Antibody SKU: | PACO60649 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Deuterosome assembly protein 1 protein (217-292AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60649 diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). |
| Synonyms: | Deuterosome assembly protein 1 (Coiled-coil domain-containing protein 67), DEUP1, CCDC67 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q05D60 |
| NCBI GenInfo Identifier: | 116812628 |
| NCBI Gene ID: | 159989 |
| NCBI Accession: | NP_857596 |
| UniProt Secondary Accession: | Q05D60 |
| UniProt Related Accession: | Q05D60 |
| Molecular Weight: | 71kDa |
| NCBI Full Name: | deuterosome assembly protein 1 |
| NCBI Synonym Full Names: | deuterosome assembly protein 1 |
| NCBI Official Symbol: | DEUP1 |
| NCBI Official Synonym Symbols: | CCDC67 |
| NCBI Protein Information: | deuterosome assembly protein 1 |
| UniProt Protein Name: | Deuterosome protein 1 |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 67 |
| Protein Family: | |
| UniProt Gene Name: | CCDC67 |
| UniProt Entry Name: | DEUP1_HUMAN |
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