DENND2D Antibody (PACO42182)
- SKU:
- PACO42182
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DENND2D Antibody (PACO42182) |
| Antibody SKU: | PACO42182 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DENN domain-containing protein 2D protein (1-233AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: DENND2D antibody at 4µg/ml + MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 54 kDa. Observed band size: 54 kDa. |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO42182 at dilution of 1:100. |
| Background: | Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
| Synonyms: | DENN domain-containing protein 2D, DENND2D |
| UniProt Protein Function: | DENND2D: a guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions. Two isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, RabChromosomal Location of Human Ortholog: 1p13.3Cellular Component: cytoplasmMolecular Function: protein binding; Rab guanyl-nucleotide exchange factor activityBiological Process: positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H6A0 |
| NCBI GenInfo Identifier: | 426214085 |
| NCBI Gene ID: | 79961 |
| NCBI Accession: | NP_001258762.1 |
| UniProt Secondary Accession: | Q9H6A0,Q5T5V6, Q9BSU0 |
| UniProt Related Accession: | Q9H6A0 |
| Molecular Weight: | 53,148 Da |
| NCBI Full Name: | DENN domain-containing protein 2D isoform b |
| NCBI Synonym Full Names: | DENN/MADD domain containing 2D |
| NCBI Official Symbol: | DENND2D |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | DENN domain-containing protein 2D |
| UniProt Protein Name: | DENN domain-containing protein 2D |
| UniProt Synonym Protein Names: | |
| Protein Family: | DENN domain-containing protein |
| UniProt Gene Name: | DENND2D |
| UniProt Entry Name: | DEN2D_HUMAN |
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