DENND1C Antibody (PACO52518)
- SKU:
- PACO52518
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DENND1C Antibody (PACO52518) |
| Antibody SKU: | PACO52518 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human DENN domain-containing protein 1C protein (601-801AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat liver tissue, Rat lung tissue. All lanes: DENND1C antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 88, 83 kDa. Observed band size: 88 kDa. |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO52518 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human lymph node tissue using PACO52518 at dilution of 1:100. |
| Background: | Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. |
| Synonyms: | DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C), DENND1C, FAM31C |
| UniProt Protein Function: | DENND1C: a guanine nucleotide exchange factor (GEF) associated with clathrin-associated vesicles. Appears to activate RAB35, RAB8A, and RAB13. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rab; GEFsChromosomal Location of Human Ortholog: 19p13.3Cellular Component: clathrin-coated vesicle; cytosolMolecular Function: Rab guanyl-nucleotide exchange factor activity |
| UniProt Protein Details: | |
| NCBI Summary: | Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q8IV53 |
| NCBI GenInfo Identifier: | 594140615 |
| NCBI Gene ID: | 79958 |
| NCBI Accession: | NP_001277260.1 |
| UniProt Secondary Accession: | Q8IV53,Q8NDB1, Q9H5Z2, B4E051, D3PFD4 |
| UniProt Related Accession: | Q8IV53 |
| Molecular Weight: | 87,065 Da |
| NCBI Full Name: | DENN domain-containing protein 1C isoform 2 |
| NCBI Synonym Full Names: | DENN/MADD domain containing 1C |
| NCBI Official Symbol: | DENND1C |
| NCBI Official Synonym Symbols: | FAM31C |
| NCBI Protein Information: | DENN domain-containing protein 1C; connecdenn 3; family with sequence similarity 31, member C |
| UniProt Protein Name: | DENN domain-containing protein 1C |
| UniProt Synonym Protein Names: | Connecdenn 3; Protein FAM31C |
| Protein Family: | DENN domain-containing protein |
| UniProt Gene Name: | DENND1C |
| UniProt Entry Name: | DEN1C_HUMAN |
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