Antibody Name:	DEAF1 Antibody (PACO19552)
Antibody SKU:	PACO19552
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human DEAF1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19552(DEAF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19552(DEAF1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Suppressin, also known as DEAF1 (deformed epidermal autoregulatory factor 1), SPN, NUDR (nuclear DEAF-1-related transcriptional regulator), or ZMYND5 (zinc finger MYND domain-containing protein 5), is a transcription factor required for embryonic development. Suppressin contains one SAND domain and one C-terminal MYND-type zinc finger. It interacts with LMO4 and CLIM-2, suggesting that it plays a role mediating cell fate and embryonic pattern formation. Suppressin is expressed in a variety of tissues and localizes to the nucleus. Several isoforms exist due to alternative splicing and, depending on the isoform, Suppressin is secreted in some cell types. Secreted Suppressin can function to inhibit cell proliferation, arresting cells in the G0 or G1 phase. Mutations in the gene encoding Suppressin may result in a growth advantage leading to the development and progression of neoplasia. This suggest that Supressin is a potential target for cancer therapy.

Synonyms:

DEAF1 transcription factor

UniProt Protein Function:	DEAF1: a transcription factor that binds to its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE). Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.Protein type: Transcription, coactivator/corepressor; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleusMolecular Function: protein binding; transcription factor activityBiological Process: anatomical structure morphogenesis; embryonic skeletal development; germ cell development; negative regulation of transcription, DNA-dependent; neural tube closure; positive regulation of transcription, DNA-dependent; regulation of mammary gland epithelial cell proliferation; regulation of transcription from RNA polymerase II promoterDisease: Mental Retardation, Autosomal Dominant 24
UniProt Protein Details:
NCBI Summary:	This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
UniProt Code:	O75398
NCBI GenInfo Identifier:	22256747
NCBI Gene ID:	10522
NCBI Accession:	O75398.1
UniProt Secondary Accession:	O75398,O15152, O75399, O75510, O75511, O75512, O75513 Q9UET1, A8K1F8, A8K5R8
UniProt Related Accession:	O75398
Molecular Weight:	51,277 Da
NCBI Full Name:	Deformed epidermal autoregulatory factor 1 homolog
NCBI Synonym Full Names:	DEAF1, transcription factor
NCBI Official Symbol:	DEAF1
NCBI Official Synonym Symbols:	SPN; NUDR; MRD24; ZMYND5
NCBI Protein Information:	deformed epidermal autoregulatory factor 1 homolog
UniProt Protein Name:	Deformed epidermal autoregulatory factor 1 homolog
UniProt Synonym Protein Names:	Nuclear DEAF-1-related transcriptional regulator; NUDR; Suppressin; Zinc finger MYND domain-containing protein 5
Protein Family:	Deformed epidermal autoregulatory factor
UniProt Gene Name:	DEAF1
UniProt Entry Name:	DEAF1_HUMAN