Antibody Name:	DDX19B Antibody (PACO16167)
Antibody SKU:	PACO16167
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Fusion protein of human DDX19B

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16167(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO16167(DDX19B Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16167(DDX19B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B

UniProt Protein Function:	DDX19B: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.13; Helicase; RNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: cytoplasm; membrane; nuclear envelope; nuclear membrane; nuclear pore; nucleusMolecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; RNA bindingBiological Process: mRNA export from nucleus; protein transport; RNA secondary structure unwinding
UniProt Protein Details:
NCBI Summary:	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UMR2
NCBI GenInfo Identifier:	10719979
NCBI Gene ID:	11269
NCBI Accession:	Q9UMR2.1
UniProt Secondary Accession:	Q9UMR2,Q6FIB7, Q6IAE0, Q96KE7, Q9H0U0, B3KNE9, B4DXS6 E7EMK4
UniProt Related Accession:	Q9UMR2
Molecular Weight:	51,063 Da
NCBI Full Name:	ATP-dependent RNA helicase DDX19B
NCBI Synonym Full Names:	DEAD-box helicase 19B
NCBI Official Symbol:	DDX19B
NCBI Official Synonym Symbols:	DBP5; RNAh; DDX19
NCBI Protein Information:	ATP-dependent RNA helicase DDX19B
UniProt Protein Name:	ATP-dependent RNA helicase DDX19B
UniProt Synonym Protein Names:	DEAD box RNA helicase DEAD5; DEAD box protein 19B
Protein Family:	ATP-dependent RNA helicase
UniProt Gene Name:	DDX19B
UniProt Entry Name:	DD19B_HUMAN