DDIT4L Antibody (PACO16165)
- SKU:
- PACO16165
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DDIT4L Antibody (PACO16165) |
| Antibody SKU: | PACO16165 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DDIT4L |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16165(DDIT4L Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid, cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology. |
| Synonyms: | DNA-damage-inducible transcript 4-like |
| UniProt Protein Function: | DDIT4L: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 4q24Cellular Component: cytoplasmMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96D03 |
| NCBI GenInfo Identifier: | 74731396 |
| NCBI Gene ID: | 115265 |
| NCBI Accession: | Q96D03.1 |
| UniProt Secondary Accession: | Q96D03,B2R7C3 |
| UniProt Related Accession: | Q96D03 |
| Molecular Weight: | 21,740 Da |
| NCBI Full Name: | DNA damage-inducible transcript 4-like protein |
| NCBI Synonym Full Names: | DNA damage inducible transcript 4 like |
| NCBI Official Symbol: | DDIT4L |
| NCBI Official Synonym Symbols: | REDD2; Rtp801L |
| NCBI Protein Information: | DNA damage-inducible transcript 4-like protein |
| UniProt Protein Name: | DNA damage-inducible transcript 4-like protein |
| UniProt Synonym Protein Names: | HIF-1 responsive protein RTP801-like; Protein regulated in development and DNA damage response 2; REDD-2 |
| Protein Family: | DNA damage-inducible transcript 4-like protein |
| UniProt Gene Name: | DDIT4L |
| UniProt Entry Name: | DDT4L_HUMAN |
| Antibodies |
| DDIT4L Antibody (PACO08779) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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