DCTN4 Antibody (PACO16157)
- SKU:
- PACO16157
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DCTN4 Antibody (PACO16157) |
| Antibody SKU: | PACO16157 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human DCTN4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16157(DCTN4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16157(DCTN4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton. |
| Synonyms: | dynactin 4 (p62) |
| UniProt Protein Function: | dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-bindingChromosomal Location of Human Ortholog: 5q33.1Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleusMolecular Function: protein binding; protein N-terminus bindingBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9UJW0 |
| NCBI GenInfo Identifier: | 62900106 |
| NCBI Gene ID: | 51164 |
| NCBI Accession: | Q9UJW0.1 |
| UniProt Secondary Accession: | Q9UJW0,Q8TAN8, B3KWW0, D3DQH0, E5RGT5 |
| UniProt Related Accession: | Q9UJW0 |
| Molecular Weight: | 53,152 Da |
| NCBI Full Name: | Dynactin subunit 4 |
| NCBI Synonym Full Names: | dynactin subunit 4 |
| NCBI Official Symbol: | DCTN4 |
| NCBI Official Synonym Symbols: | P62; DYN4 |
| NCBI Protein Information: | dynactin subunit 4 |
| UniProt Protein Name: | Dynactin subunit 4 |
| UniProt Synonym Protein Names: | Dynactin subunit p62 |
| Protein Family: | Dynactin |
| UniProt Gene Name: | DCTN4 |
| UniProt Entry Name: | DCTN4_HUMAN |
| Antibodies |
| DCTN4 Antibody (PACO08765) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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