DCTN3 Polyclonal Antibody
- SKU:
- CAB8190
Description
| Product Name: | DCTN3 Polyclonal Antibody |
| Product Code: | CAB8190 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Chromosome, Cleavage furrow, Cytoplasm, Midbody, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, spindle |
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DCTN3 (NP_077324.1). |
| Sequence: | MAGLT DLQRL QARVE ELERW VYGPG GARGS RKVAD GLVKV QVALG NISSK RERVK ILYKK IEDLI KYLDP EYIDR IAIPD ASKLQ FILAE EQFIL SQVAL LEQVN ALVPM LDSAH IKAVP EHAAR LQRLA QIHIQ QQAPW GVGVR DEAGS LVEDV GFAQF LSVLH FGPTG PVCGN H |
| Synonyms: | DCTN22, DCTN-22 |
| Calculated MW: | 21kDa |
| Observed MW: | Refer to figures |