DCLK2 Antibody (PACO21896)
- SKU:
- PACO21896
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DCLK2 Antibody (PACO21896) |
| Antibody SKU: | PACO21896 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human DCLK2. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using DCLK2 antibody. |
| Background: | Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm By similarity. Hillier L.W., Nature 434:724-731(2005). |
| Synonyms: | Serine/threonine-protein kinase DCLK2; EC 2.7.11.1; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; DCLK2 |
| UniProt Protein Function: | DCAMKL2: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DCAMKL family Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: cytoskeleton; cytoplasm Molecular Function:protein serine/threonine kinase activity; ATP binding Biological Process: protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q8N568 |
| NCBI GenInfo Identifier: | 156713428 |
| NCBI Gene ID: | 166614 |
| NCBI Accession: | NP_001035350.2 |
| UniProt Secondary Accession: | Q8N568,Q59GC8, Q8N399, C9J5Q9, |
| UniProt Related Accession: | Q8N568 |
| Molecular Weight: | 85,384 Da |
| NCBI Full Name: | serine/threonine-protein kinase DCLK2 isoform a |
| NCBI Synonym Full Names: | doublecortin-like kinase 2 |
| NCBI Official Symbol: | DCLK2 |
| NCBI Official Synonym Symbols: | CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II |
| NCBI Protein Information: | serine/threonine-protein kinase DCLK2 |
| UniProt Protein Name: | Serine/threonine-protein kinase DCLK2 |
| UniProt Synonym Protein Names: | CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | DCLK2 |
| UniProt Entry Name: | DCLK2_HUMAN |
| Antibodies | ELISA Kits |
| DCLK2 Antibody (PACO00688) | DCLK2 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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