Antibody Name:	DCBLD2 Antibody (PACO16145)
Antibody SKU:	PACO16145
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Fusion protein of human DCBLD2

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16145(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16145(DCBLD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

CLCP1 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1), also known as DCBLD2 (discoidin, CUB and LCCL domain containing 2) or ESDN, is a 775 amino acid, single-pass type I membrane protein that contains one CUB domain, one LCCL domain and one F5/8 type C domain. Expressed at high levels in heart, testis and skeletal muscle, CLCP1 is thought to regulate vascular smooth muscle cell (VSMC) proliferation and remodeling and may be involved in the transformation and metastasis of various cancers, such as metastatic lung cancer and gastric carcinoma.

Synonyms:

discoidin, CUB and LCCL domain containing 2

UniProt Protein Function:	DCBLD2: a type-I transmembrane protein. May be involved in vascular remodeling and influence vascular smooth muscle cell proliferation. Contains a CUB domain and a coagulation factor V/VIII homology domain, similar to the structure of the neuropilins. Plays a role in cell motility. SEMA4B appears to be one of its ligands. Strongly expressed in nerve bundles. Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells. Increased in lung cancers during the process of tumor progression. A target of EGF signaling in the A431 cervical cancer cell-line. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 3q12.1\|3Cellular Component: cell surface; integral to plasma membraneMolecular Function: protein bindingBiological Process: negative regulation of cell growth; wound healing
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q96PD2
NCBI GenInfo Identifier:	57013820
NCBI Gene ID:	131566
NCBI Accession:	Q96PD2.1
UniProt Secondary Accession:	Q96PD2,Q8N6M4, Q8TDX2, B7WNL1, D3DN41
UniProt Related Accession:	Q96PD2
Molecular Weight:	86,657 Da
NCBI Full Name:	Discoidin, CUB and LCCL domain-containing protein 2
NCBI Synonym Full Names:	discoidin, CUB and LCCL domain containing 2
NCBI Official Symbol:	DCBLD2
NCBI Official Synonym Symbols:	ESDN; CLCP1
NCBI Protein Information:	discoidin, CUB and LCCL domain-containing protein 2
UniProt Protein Name:	Discoidin, CUB and LCCL domain-containing protein 2
UniProt Synonym Protein Names:	CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein
Protein Family:	Discoidin, CUB and LCCL domain-containing protein
UniProt Gene Name:	DCBLD2
UniProt Entry Name:	DCBD2_HUMAN