DBR1 Antibody (PACO47226)
- SKU:
- PACO47226
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | DBR1 Antibody (PACO47226) |
| Antibody SKU: | PACO47226 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Lariat debranching enzyme protein (1-220AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO47226 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO47226 at dilution of 1:100. |
| Background: | Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. |
| Synonyms: | Lariat debranching enzyme (EC 3.1), DBR1 |
| UniProt Protein Function: | DBR1: Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via a RNA lariat intermediate in cDNA synthesis. Belongs to the lariat debranching enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.-.-; RNA processing; RNA splicingChromosomal Location of Human Ortholog: 3q22.3Cellular Component: nucleusMolecular Function: RNA lariat debranching enzyme activityBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UK59 |
| NCBI GenInfo Identifier: | 56549113 |
| NCBI Gene ID: | 51163 |
| NCBI Accession: | NP_057300.2 |
| UniProt Secondary Accession: | Q9UK59,Q96GH0, Q9NXQ6 |
| UniProt Related Accession: | Q9UK59 |
| Molecular Weight: | 35,022 Da |
| NCBI Full Name: | lariat debranching enzyme |
| NCBI Synonym Full Names: | debranching RNA lariats 1 |
| NCBI Official Symbol: | DBR1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | lariat debranching enzyme |
| UniProt Protein Name: | Lariat debranching enzyme |
| UniProt Synonym Protein Names: | |
| Protein Family: | Lariat debranching enzyme |
| UniProt Gene Name: | DBR1 |
| UniProt Entry Name: | DBR1_HUMAN |
| Antibodies |
| DBR1 Antibody (PACO08753) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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