Description
Antibody Name: | DAZ4 Antibody (PACO13803) |
Antibody SKU: | PACO13803 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:500-1:5000, IHC:1:5-1:20 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human DAZ4 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO13803(DAZ4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13803(DAZ4 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. |
Synonyms: | Deleted in azoospermia protein 4 |
UniProt Protein Function: | DAZ4: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Defects in DAZ4 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Yq11.223Disease: Spermatogenic Failure, Y-linked, 2 |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011] |
UniProt Code: | Q86SG3 |
NCBI GenInfo Identifier: | 44887840 |
NCBI Gene ID: | 57135 |
NCBI Accession: | Q86SG3.2 |
UniProt Secondary Accession: | Q86SG3,Q9NR88, Q9NR89 |
UniProt Related Accession: | Q86SG3 |
Molecular Weight: | 44,085 Da |
NCBI Full Name: | Deleted in azoospermia protein 4 |
NCBI Synonym Full Names: | deleted in azoospermia 4 |
NCBI Official Symbol: | DAZ4 |
NCBI Official Synonym Symbols: | pDP1680; pDP1681 |
NCBI Protein Information: | deleted in azoospermia protein 4 |
UniProt Protein Name: | Deleted in azoospermia protein 4 |
UniProt Synonym Protein Names: | |
Protein Family: | Deleted in azoospermia protein |
UniProt Gene Name: | DAZ4 |
UniProt Entry Name: | DAZ4_HUMAN |