DAB2 Polyclonal Antibody
- SKU:
- CAB3822
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- FC
Description
| Product Name: | DAB2 Polyclonal Antibody |
| Product Code: | CAB3822 |
| Reactivity: | Human |
| Applications: | Western blotting, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, FC, ELISA |
| Key Applications: | Western blotting, Flow Cytometry |
| Recommended Dilution: | WB 1:500-1:1000, FC 1:20-1:50 |
| Storage Buffer: | Store at 4°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Membrane, clathrin-coated pit, clathrin-coated vesicle membrane |
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | A synthetic peptide of human DAB2 |
| Sequence: | Email for sequence |
| Synonyms: | DOC2, DOC-2 |
| Calculated MW: | 82kDa |
| Observed MW: | 96kDa |
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