Cytochrome P450 2E1 (CYP2E1) Monoclonal Antibody (CAB22629)
- SKU:
- CAB22629
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Cytochrome P450 2E1 (CYP2E1) Monoclonal Antibody |
| Product Code: | CAB22629 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC58003 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:20000, IHC-P 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse liver, Rat liver |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Customer Validation: | WB(Rattus norvegicus) |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1 (NP_000764.1) |
| Sequence: | KVIKN VAEVK EYVSE RVKEH HQSLD PNCPR DLTDC LLVEM EKEKH SAERL YTMDG ITVTV ADLFF AGTET TSTTL RYGLL ILMKY PEIEE KLHEE IDRVI GPSRI PAIKD RQEMP YMDAV VHEIQ RFITL VPSNL PHEAT RDTIF RGYLI PKGTV VVPTL DSVLY DNQEF PDPEK FKPEH FLNEN GKFKY SDYFK PFSTG KRVCA GEGLA RMELF LLLCA ILQHF NLKPL VDPKD IDLSP IHIGF GCIPP RYKLC VIPRS |
| Synonyms: | CPE1, CYP2E, P450-J, P450C2E |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
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