CYP3A7 Antibody (PACO22778)
- SKU:
- PACO22778
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CYP3A7 Antibody (PACO22778) |
| Antibody SKU: | PACO22778 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human Cytochrome P450 3A7. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using Cytochrome P450 3A7 antibody. |
| Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3AP1 pseudogene and is represented by GeneID:100861540. |
| Synonyms: | Cytochrome P450; family 3; subfamily A; polypeptide 7; CYP3A7 |
| UniProt Protein Function: | CYP3A7: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1Chromosomal Location of Human Ortholog: 7q22.1Cellular Component: endoplasmic reticulum membraneMolecular Function: iron ion binding; heme binding; oxygen binding; monooxygenase activityBiological Process: xenobiotic metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015] |
| UniProt Code: | A4D288 |
| NCBI GenInfo Identifier: | 608788370 |
| NCBI Gene ID: | 1551 |
| NCBI Accession: | NP_000756.3 |
| UniProt Secondary Accession: | A4D288,Q9H241, A4D288 |
| UniProt Related Accession: | A4D288,P24462 |
| Molecular Weight: | 61,547 Da |
| NCBI Full Name: | cytochrome P450 3A7 |
| NCBI Synonym Full Names: | cytochrome P450, family 3, subfamily A, polypeptide 7 |
| NCBI Official Symbol: | CYP3A7 |
| NCBI Official Synonym Symbols: | CP37; CYPIIIA7; P450-HFLA; P-450111A7; P-450(HFL33) |
| NCBI Protein Information: | cytochrome P450 3A7 |
| UniProt Protein Name: | Cytochrome P450 3A7 |
| UniProt Synonym Protein Names: | CYPIIIA7; Cytochrome P450-HFLA |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP3A7 |
| UniProt Entry Name: | CP3A7_HUMAN |
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