CYP1A1 Monoclonal Antibody
- SKU:
- CAB22182
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | CYP1A1 Monoclonal Antibody |
| Product Code: | CAB22182 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52230 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein |
| Customer Validation: | WB(Mus musculus) |
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CYP1A1 (NP_000490.1). |
| Sequence: | AFKDL NEKFY SFMQK MVKEH YKTFE KGHIR DITDS LIEHC QEKQL DENAN VQLSD EKIIN IVLDL FGAGF DTVTT AISWS LMYLV MNPRV QRKIQ EELDT V |
| Synonyms: | AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX |
| Calculated MW: | 58kDa |
| Observed MW: | 58kDa |
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