cyp125 Antibody (PACO34598)
- SKU:
- PACO34598
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | cyp125 Antibody (PACO34598) |
| Antibody SKU: | PACO34598 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mycobacterium tuberculosis |
| Immunogen: | Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Catalyzes the C-27 hydroxylation of cholest-4-en-3-one and cholesterol and subsequently oxidizes the alcohol of the former to the cholest-4-en-3-one-27-oic acid, via the aldehyde intermediate. Not required to incorporate the cholesterol side-chain carbon atoms into cellular lipids. |
| Synonyms: | Steroid C26-monooxygenase (EC 1.14.13.141) (Cholest-4-en-3-one 26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 125) (Steroid C27-monooxygenase), cyp125, cyp125A1 |
| UniProt Protein Function: | Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20843794, PubMed:20545858). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate (PubMed:19846551, PubMed:20843794, PubMed:20545858). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:19846551, PubMed:20843794, PubMed:20545858). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P9WPP1 |
| NCBI GenInfo Identifier: | 15610681 |
| NCBI Gene ID: | 887782 |
| NCBI Accession: | NP_218062.1 |
| UniProt Secondary Accession: | P9WPP1,P63709, P71856, L0TEH2 |
| UniProt Related Accession: | P9WPP1 |
| Molecular Weight: | 50.4kD |
| NCBI Full Name: | steroid C26-monooxygenase |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | cyp125 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | steroid C26-monooxygenase |
| UniProt Protein Name: | Steroid C26-monooxygenase |
| UniProt Synonym Protein Names: | Cholest-4-en-3-one 26-monooxygenase |
| Protein Family: | Steroid C26-monooxygenase |
| UniProt Gene Name: | cyp125 |
| UniProt Entry Name: |
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