Cynomolgus CTLA-4/CD152 Recombinant Protein (RPES3135)
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- SKU:
- RPES3135
- Product Type:
- Recombinant Protein
- Species:
- Monkey
Description
system_update_altDatasheet
Cynomolgus CTLA-4/CD152 Recombinant Protein
Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
| Product Name: | Cynomolgus CTLA-4/CD152 Recombinant Protein (RPES3135) |
| Product Code: | RPES3135 |
| Size: | 10µg |
| Species: | Cynomolgus |
| Expressed Host: | Human Cells |
| Synonyms: | Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4 |
| Accession: | G7PL88 |
| Sequence: | Ala37-Ser160 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Cynomolgus CTLA-4 is produced by our Mammalian expression system and the target gene encoding Ala37-Ser160 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 40.2 kDa |
| AP Mol Mass: | 45-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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