CYFIP2 Antibody (PACO16099)
- SKU:
- PACO16099
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CYFIP2 Antibody (PACO16099) |
| Antibody SKU: | PACO16099 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human CYFIP2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16099(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: PACO16099(CYFIP2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16099(CYFIP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid, protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
| Synonyms: | cytoplasmic FMR1 interacting protein 2 |
| UniProt Protein Function: | CYFIP2: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. Belongs to the CYFIP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: neuron projection; membrane; perinuclear region of cytoplasm; cytoplasm; synapse; cell junction; cytosol Molecular Function:protein binding Biological Process: cell-cell adhesion; positive regulation of proteolysis; apoptosis; innate immune response; vascular endothelial growth factor receptor signaling pathway |
| UniProt Code: | Q96F07 |
| NCBI GenInfo Identifier: | 134034199 |
| NCBI Gene ID: | 26999 |
| NCBI Accession: | Q96F07.2 |
| UniProt Related Accession: | Q96F07 |
| Molecular Weight: | |
| NCBI Full Name: | Cytoplasmic FMR1-interacting protein 2 |
| NCBI Synonym Full Names: | cytoplasmic FMR1 interacting protein 2 |
| NCBI Official Symbol: | CYFIP2 |
| NCBI Official Synonym Symbols: | EIEE65; PIR121 |
| NCBI Protein Information: | cytoplasmic FMR1-interacting protein 2 |
| UniProt Protein Name: | Cytoplasmic FMR1-interacting protein 2 |
| UniProt Synonym Protein Names: | p53-inducible protein 121 |
| Protein Family: | Cytoplasmic FMR1-interacting protein |
| UniProt Gene Name: | CYFIP2 |
| UniProt Entry Name: | CYFP2_HUMAN |
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