Cyclin D1 Monoclonal Antibody
- SKU:
- CAB22104
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Cyclin D1 Monoclonal Antibody |
| Product Code: | CAB22104 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51669 |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | C6, Mouse lung |
| Cellular Location: | Cytoplasm, Membrane, Nucleus |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human Cyclin D1 (NP_444284.1). |
| Sequence: | WNLAA MTPHD FIEHF LSKMP EAEEN KQIIR KHAQT FVALC ATDVK FISNP PSMVA AGSVV AAVQG LNLRS PNNFL SYYRL TRFLS RVIKC DPDCL RACQE Q |
| Synonyms: | BCL1, PRAD1, U21B31, D11S287E |
| Calculated MW: | 34kDa |
| Observed MW: | 35kDa |
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