CYB5R2 Antibody (PACO36670)
- SKU:
- PACO36670
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CYB5R2 Antibody (PACO36670) |
| Antibody SKU: | PACO36670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human NADH-cytochrome b5 reductase 2 protein (1-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CYB5R2 antibody at 4µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 28 kDa. Observed band size: 32 kDa. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO36670 at dilution of 1:100. |
| Background: | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acid, , cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). |
| Synonyms: | NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2), CYB5R2 |
| UniProt Protein Function: | CYB5R2: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.6.2.2 Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: endoplasmic reticulum membrane; membrane; nucleus Molecular Function:cytochrome-b5 reductase activity; protein binding Biological Process: bicarbonate transport |
| NCBI Summary: | The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q6BCY4 |
| NCBI GenInfo Identifier: | 74709211 |
| NCBI Gene ID: | 51700 |
| NCBI Accession: | Q6BCY4.1 |
| UniProt Secondary Accession: | Q6BCY4,Q9BVA3, Q9UF68, Q9UHJ0, |
| UniProt Related Accession: | Q6BCY4 |
| Molecular Weight: | 27,043 Da |
| NCBI Full Name: | NADH-cytochrome b5 reductase 2 |
| NCBI Synonym Full Names: | cytochrome b5 reductase 2 |
| NCBI Official Symbol: | CYB5R2 |
| NCBI Official Synonym Symbols: | B5R.2 |
| NCBI Protein Information: | NADH-cytochrome b5 reductase 2 |
| UniProt Protein Name: | NADH-cytochrome b5 reductase 2 |
| Protein Family: | NADH-cytochrome b5 reductase |
| UniProt Gene Name: | CYB5R2 |
| UniProt Entry Name: | NB5R2_HUMAN |
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