CUX1 Antibody (PACO62255)
- SKU:
- PACO62255
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CUX1 Antibody (PACO62255) |
| Antibody SKU: | PACO62255 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeobox protein cut-like 1 protein (24-94AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO62255 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) β enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR β enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity). |
| Synonyms: | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein cux-1), CUX1, CUTL1 |
| UniProt Protein Function: | CUTL1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to Golgi membrane; nucleus; cytosol Molecular Function:sequence-specific DNA binding; chromatin binding Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development |
| NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P39880 |
| NCBI GenInfo Identifier: | 296439379 |
| NCBI Gene ID: | 1523 |
| NCBI Accession: | P39880.3 |
| UniProt Secondary Accession: | P39880,Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5 B3KV79, J3KQV9, |
| UniProt Related Accession: | P39880,Q13948 |
| Molecular Weight: | 77 kDa |
| NCBI Full Name: | Homeobox protein cut-like 1 |
| NCBI Synonym Full Names: | cut-like homeobox 1 |
| NCBI Official Symbol: | CUX1 |
| NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 |
| NCBI Protein Information: | protein CASP; cut homolog; homeobox protein cux-1; CCAAT displacement protein; golgi integral membrane protein 6; putative protein product of Nbla10317 |
| UniProt Protein Name: | Homeobox protein cut-like 1 |
| UniProt Synonym Protein Names: | CCAAT displacement protein; CDP; Homeobox protein cux-1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CUX1 |
| UniProt Entry Name: | CUX1_HUMAN |
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