UniProt Protein Function: | CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor; Membrane protein, integral; DNA-binding Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus Molecular Function:protein-tyrosine kinase activity; sequence-specific DNA binding Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
UniProt Code: | Q13948 |
NCBI GenInfo Identifier: | 85681028 |
NCBI Gene ID: | 1523 |
NCBI Accession: | Q13948.2 |
UniProt Secondary Accession: | Q13948,Q53GU9, Q8TBS3, B3KWH3, B3KWH8, B4DZZ2, G3V1Z6 J3KPQ6, |
UniProt Related Accession: | Q13948,P39880 |
Molecular Weight: | 75,644 Da |
NCBI Full Name: | Protein CASP |
NCBI Synonym Full Names: | cut like homeobox 1 |
NCBI Official Symbol: | CUX1 |
NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 |
NCBI Protein Information: | protein CASP |
UniProt Protein Name: | Protein CASP |
Protein Family: | Homeobox protein |
UniProt Gene Name: | CUX1 |
UniProt Entry Name: | CASP_HUMAN |