CUX1 Antibody (PACO58120)
- SKU:
- PACO58120
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CUX1 Antibody (PACO58120) |
| Antibody SKU: | PACO58120 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Protein CASP protein (50-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: SH-SY5Y whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, Rat brain tissue, Rat liver tissue, Rat kidney tissue, Mouse brain tissue. All lanes: CUX1 antibody at 3.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 78, 73, 165, 162, 166, 154, 158, 148, 76 kDa. Observed band size: 78 kDa. |
 | IHC image of PACO58120 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | May be involved in intra-Golgi retrograde transport. |
| Synonyms: | Protein CASP, CUX1, CUTL1 |
| UniProt Protein Function: | CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Membrane protein, integral; DNA-binding Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus Molecular Function:protein-tyrosine kinase activity; sequence-specific DNA binding Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q13948 |
| NCBI GenInfo Identifier: | 85681028 |
| NCBI Gene ID: | 1523 |
| NCBI Accession: | Q13948.2 |
| UniProt Secondary Accession: | Q13948,Q53GU9, Q8TBS3, B3KWH3, B3KWH8, B4DZZ2, G3V1Z6 J3KPQ6, |
| UniProt Related Accession: | Q13948,P39880 |
| Molecular Weight: | 75,644 Da |
| NCBI Full Name: | Protein CASP |
| NCBI Synonym Full Names: | cut like homeobox 1 |
| NCBI Official Symbol: | CUX1 |
| NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 |
| NCBI Protein Information: | protein CASP |
| UniProt Protein Name: | Protein CASP |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CUX1 |
| UniProt Entry Name: | CASP_HUMAN |
| Antibodies |
| CUX1 Antibody (PACO08681) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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