Name: CUL7 Antibody (PACO14300)
SKU: PACO14300
Availability: OutOfStock

Antibody Name:	CUL7 Antibody (PACO14300)
Antibody SKU:	PACO14300
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Rat
Immunogen:	Fusion protein of human CUL7

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14300(CUL7 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14300(CUL7 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:	The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:	cullin 7

UniProt Protein Function:	CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; microtubule cytoskeleton organization and biogenesis; positive regulation of dendrite morphogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; epithelial to mesenchymal transition; regulation of mitosis; vasculogenesis; Golgi organization and biogenesis; placenta developmentDisease: Three M Syndrome 1
UniProt Protein Details:
NCBI Summary:	The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Code:	Q14999
NCBI GenInfo Identifier:	21707140
NCBI Gene ID:	9820
NCBI Accession:	AAH33647
UniProt Secondary Accession:	Q14999,Q5T654, B4DYZ0, F5H0L1
UniProt Related Accession:	Q14999
Molecular Weight:	199,750 Da
NCBI Full Name:	Cullin 7
NCBI Synonym Full Names:	cullin 7
NCBI Official Symbol:	CUL7
NCBI Official Synonym Symbols:	3M1; KIAA0076; dJ20C7.5
NCBI Protein Information:	cullin-7
UniProt Protein Name:	Cullin-7
UniProt Synonym Protein Names:
Protein Family:	Cullin
UniProt Gene Name:	CUL7
UniProt Entry Name:	CUL7_HUMAN