Name: Ctss Antibody (PACO26041)
SKU: PACO26041
Availability: OutOfStock

Antibody Name:	Ctss Antibody (PACO26041)
Antibody SKU:	PACO26041
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Cathepsin S protein (123-340AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:	Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Synonyms:	Cathepsin S (EC 3.4.22.27), Ctss, Cats

UniProt Protein Function:	CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 3.4.22.27; Protease Chromosomal Location of Human Ortholog: 3 F2.1\|3 40.74 cM Cellular Component: cell surface; extracellular space; intracellular membrane-bound organelle; lysosome; membrane Molecular Function:collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; laminin binding; peptidase activity; proteoglycan binding Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen; bone resorption; collagen catabolic process; immune response; positive regulation of inflammatory response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of sensory perception of pain; response to acidity
NCBI Summary:	This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]
UniProt Code:	O70370
NCBI GenInfo Identifier:	510025483
NCBI Gene ID:	13040
NCBI Accession:	NP_067256.4
UniProt Secondary Accession:	O70370,O54973, E9QK18,
UniProt Related Accession:	O70370
Molecular Weight:	27.8kD
NCBI Full Name:	cathepsin S isoform 2 preproprotein
NCBI Synonym Full Names:	cathepsin S
NCBI Official Symbol:	Ctss
NCBI Official Synonym Symbols:	Cats
NCBI Protein Information:	cathepsin S
UniProt Protein Name:	Cathepsin S
Protein Family:	Cathepsin
UniProt Gene Name:	Ctss