CTLA 4 Monoclonal Antibody [RYNmCTLA-4] (CPAB0349)

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SKU:
CPAB0349
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
RYNmCTLA-4

Description

system_update_alt Datasheet
Product Name:CTLA 4 Antibody
Product Sku:CPAB0349
Size:500
Host Species:Hamster
Immunogen:mixture of mouse activated T cells.
Clone:RYNmCTLA-4.
Reactivity:Mouse
Applications:
Purification Method:Ion exchange column.
Isotype:IgG
Background:CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Synonyms:GSE, CD152, IDDM12, CELIAC3, CTLA-4.
Storage Buffer:Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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