CTCF Polyclonal Antibody
- SKU:
- CAB21337
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | CTCF Polyclonal Antibody |
| Product Code: | CAB21337 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:100-1:500, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Chromosome, Nucleus, centromere, nucleoplasm |
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1). |
| Sequence: | MEGDA VEAIV EESET FIKGK ERKTY QRRRE GGQEE DACHL PQNQT DGGEV VQDVN SSVQM VMMEQ LDPTL LQMKT EVMEG TVAPE AEAAV DDTQI ITLQV VNMEE QPINI GELQL VQVPV PVTVP VATTS VEELQ GAYEN EVSKE GLAES EPMIC HTLPL PEGFQ VVKVG ANGEV ETLEQ GELPP QEDPS WQKDP DYQPP AKKTK KTKKS KLRYT EEGKD VDVSV YDFEE EQQEG LLSEV NAEKV VGNMK PPKPT KIKKK |
| Synonyms: | MRD21, FAP108, CFAP108 |
| Calculated MW: | 83kDa |
| Observed MW: | 140kDa |
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