CTAGE5 Antibody (PACO58725)
- SKU:
- PACO58725
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CTAGE5 Antibody (PACO58725) |
| Antibody SKU: | PACO58725 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Endoplasmic reticulum export factor CTAGE5 protein (515-632AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58725 diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites. |
| Synonyms: | Endoplasmic reticulum export factor CTAGE5 (CTAGE family member 5 ER export factor) (Protein cTAGE-5) (Meningioma-expressed antigen 6/11), CTAGE5, MEA11 MEA6 MGEA11 MGEA6 |
| UniProt Protein Function: | CTAGE5: Tumor-associated antigen. Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Belongs to the cTAGE family. 8 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Membrane protein, integralChromosomal Location of Human Ortholog: 14q13.3Cellular Component: endoplasmic reticulum membrane; membraneMolecular Function: enzyme activator activity; protein bindingBiological Process: ER to Golgi vesicle-mediated transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O15320 |
| NCBI GenInfo Identifier: | 311033477 |
| NCBI Gene ID: | 4253 |
| NCBI Accession: | O15320.4 |
| UniProt Secondary Accession: | O15320,O00169, Q6MZN2, Q6P2R8, Q86TF6, Q8IX92, Q8IX93 B3KRA6, B4DQS6, D3DSA6 |
| UniProt Related Accession: | O15320 |
| Molecular Weight: | 89,647 Da |
| NCBI Full Name: | cTAGE family member 5 |
| NCBI Synonym Full Names: | CTAGE family member 5, ER export factor |
| NCBI Official Symbol: | CTAGE5 |
| NCBI Official Synonym Symbols: | MEA6; MGEA; MGEA6; MGEA11 |
| NCBI Protein Information: | cTAGE family member 5 |
| UniProt Protein Name: | cTAGE family member 5 |
| UniProt Synonym Protein Names: | Meningioma-expressed antigen 6/11 |
| Protein Family: | cTAGE family |
| UniProt Gene Name: | CTAGE5 |
| UniProt Entry Name: | CTGE5_HUMAN |
Related Products
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH
otsB Antibody
Overview Product Name:otsB AntibodyProduct Code:PACO64885Size:50µLTarget Names:otsBSpecies Reactivity:Escherichia coli