CSMD1 Antibody (PACO19521)
- SKU:
- PACO19521
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CSMD1 Antibody (PACO19521) |
| Antibody SKU: | PACO19521 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human CSMD1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19521(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19521(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the CSMD1gene. It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas. |
| Synonyms: | CUB and Sushi multiple domains 1 |
| UniProt Protein Function: | CSMD1: Potential suppressor of squamous cell carcinomas. Belongs to the CSMD family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p23.2Cellular Component: integral to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PZ7 |
| NCBI GenInfo Identifier: | 259013213 |
| NCBI Gene ID: | 64478 |
| NCBI Accession: | NP_150094.5 |
| UniProt Secondary Accession: | Q96PZ7,Q0H0J5, Q96QU9, Q96RM4 |
| UniProt Related Accession: | Q96PZ7 |
| Molecular Weight: | |
| NCBI Full Name: | CUB and sushi domain-containing protein 1 |
| NCBI Synonym Full Names: | CUB and Sushi multiple domains 1 |
| NCBI Official Symbol: | CSMD1 |
| NCBI Official Synonym Symbols: | PPP1R24 |
| NCBI Protein Information: | CUB and sushi domain-containing protein 1 |
| UniProt Protein Name: | CUB and sushi domain-containing protein 1 |
| UniProt Synonym Protein Names: | CUB and sushi multiple domains protein 1 |
| Protein Family: | CUB and sushi domain-containing protein |
| UniProt Gene Name: | CSMD1 |
| UniProt Entry Name: | CSMD1_HUMAN |
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