CRELD2 Antibody (PACO16072)
- SKU:
- PACO16072
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CRELD2 Antibody (PACO16072) |
| Antibody SKU: | PACO16072 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human CRELD2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16072(CRELD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal colon tissue, Primary antibody: PACO16072(CRELD2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16072(CRELD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid, protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR 4, possibly regulating its transport. Human CRELD2 shares 69% amino acid, identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. |
| Synonyms: | cysteine-rich with EGF-like domains 2 |
| UniProt Protein Function: | CRELD2: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor. Belongs to the CRELD family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q13.33Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6UXH1 |
| NCBI GenInfo Identifier: | 74738218 |
| NCBI Gene ID: | 79174 |
| NCBI Accession: | Q6UXH1.1 |
| UniProt Secondary Accession: | Q6UXH1,Q4W0V0, Q86UC0, Q9BU47, A5GZA2, A5GZA3, A5GZA4 A5GZA5, A5GZA6 |
| UniProt Related Accession: | Q6UXH1 |
| Molecular Weight: | 40,491 Da |
| NCBI Full Name: | Cysteine-rich with EGF-like domain protein 2 |
| NCBI Synonym Full Names: | cysteine rich with EGF like domains 2 |
| NCBI Official Symbol: | CRELD2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cysteine-rich with EGF-like domain protein 2 |
| UniProt Protein Name: | Cysteine-rich with EGF-like domain protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cysteine-rich with EGF-like domain protein |
| UniProt Gene Name: | CRELD2 |
| UniProt Entry Name: | CREL2_HUMAN |
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