CREB3L1 Antibody (PACO50938)
- SKU:
- PACO50938
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CREB3L1 Antibody (PACO50938) |
| Antibody SKU: | PACO50938 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO50938 at dilution of 1:100. |
 | Immunofluorescent analysis of A549 cells using PACO50938 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO50938 at dilution of 1:100. |
| Background: | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A. Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. |
| Synonyms: | Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1], CREB3L1, OASIS |
| UniProt Protein Function: | CREB3L1: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus Molecular Function:sequence-specific DNA binding; chromatin binding Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of bone mineralization |
| NCBI Summary: | The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q96BA8 |
| NCBI GenInfo Identifier: | 74751763 |
| NCBI Gene ID: | 90993 |
| NCBI Accession: | Q96BA8.1 |
| UniProt Secondary Accession: | Q96BA8,Q8N2D5, Q96CP0, |
| UniProt Related Accession: | Q96BA8 |
| Molecular Weight: | 519 |
| NCBI Full Name: | Cyclic AMP-responsive element-binding protein 3-like protein 1 |
| NCBI Synonym Full Names: | cAMP responsive element binding protein 3-like 1 |
| NCBI Official Symbol: | CREB3L1 |
| NCBI Official Synonym Symbols: | OASIS |
| NCBI Protein Information: | cyclic AMP-responsive element-binding protein 3-like protein 1; BBF-2 homolog; old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1 |
| UniProt Protein Name: | Cyclic AMP-responsive element-binding protein 3-like protein 1 |
| UniProt Synonym Protein Names: | Old astrocyte specifically-induced substance; OASIS |
| Protein Family: | Cyclic AMP-responsive element-binding protein 3-like protein |
| UniProt Gene Name: | CREB3L1 |
| UniProt Entry Name: | CR3L1_HUMAN |
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