CRB2 Antibody (PACO46586)
- SKU:
- PACO46586
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CRB2 Antibody (PACO46586) |
| Antibody SKU: | PACO46586 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:1000-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein crumbs homolog 2 protein (253-483AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO46586 diluted at 1:1600 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.. |
| Background: | May play a role in polarized cells morphogenesis. |
| Synonyms: | Protein crumbs homolog 2 (Crumbs-like protein 2), CRB2 |
| UniProt Protein Function: | CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 9q33.3Cellular Component: protein complex; integral to membrane; plasma membrane; lipid raftMolecular Function: enzyme binding; aspartic-type endopeptidase inhibitor activity; calcium ion bindingBiological Process: somitogenesis; mesoderm formation; notochord formation; maintenance of epithelial cell polarity; positive regulation of BMP signaling pathwayDisease: Ventriculomegaly With Cystic Kidney Disease; Focal Segmental Glomerulosclerosis 9 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5IJ48 |
| NCBI GenInfo Identifier: | 112420992 |
| NCBI Gene ID: | 286204 |
| NCBI Accession: | NP_775960.4 |
| UniProt Secondary Accession: | Q5IJ48,Q0QD46, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6, A2A3N4 |
| UniProt Related Accession: | Q5IJ48 |
| Molecular Weight: | 134265 |
| NCBI Full Name: | protein crumbs homolog 2 |
| NCBI Synonym Full Names: | crumbs family member 2 |
| NCBI Official Symbol: | CRB2 |
| NCBI Official Synonym Symbols: | FSGS9; VMCKD |
| NCBI Protein Information: | protein crumbs homolog 2 |
| UniProt Protein Name: | Protein crumbs homolog 2 |
| UniProt Synonym Protein Names: | Crumbs-like protein 2 |
| Protein Family: | Protein crumbs |
| UniProt Gene Name: | CRB2 |
| UniProt Entry Name: | CRUM2_HUMAN |
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