Cr2 Antibody (PACO25905)
- SKU:
- PACO25905
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Cr2 Antibody (PACO25905) |
| Antibody SKU: | PACO25905 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Complement receptor type 2 protein (729-963AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Receptor for complement C3d. Participates in B lymphocytes activation. |
| Synonyms: | Complement receptor type 2 (Cr2) (Complement C3d receptor) (CD antigen CD21), Cr2 |
| UniProt Protein Function: | CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Cellular Component: membrane; integral to membrane; receptor complex; external side of plasma membraneMolecular Function: complement binding; protein binding; complement receptor activity; protein homodimerization activity; DNA binding; receptor activityBiological Process: B cell proliferation; B cell activation; immune system process; complement receptor mediated signaling pathway; B cell differentiation; innate immune response; complement activation, classical pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P19070 |
| NCBI GenInfo Identifier: | 117316 |
| NCBI Gene ID: | 12902 |
| NCBI Accession: | P19070.1 |
| UniProt Secondary Accession: | P19070 |
| UniProt Related Accession: | P19070 |
| Molecular Weight: | Predicted Molecular Mass: 26.4kDaAccurate Molecular Mass: 31kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | Complement receptor type 2 |
| NCBI Synonym Full Names: | complement receptor 2 |
| NCBI Official Symbol: | Cr2 |
| NCBI Official Synonym Symbols: | Cr1; C3DR; CD21; CD35; Cr-1; Cr-2 |
| NCBI Protein Information: | complement receptor type 2; complement C3d receptor; complement receptor type 1; expressed in B lymphocytes |
| UniProt Protein Name: | Complement receptor type 2 |
| UniProt Synonym Protein Names: | Complement C3d receptor |
| Protein Family: | Complement receptor |
| UniProt Gene Name: | Cr2 |
| UniProt Entry Name: | CR2_MOUSE |
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