CPNE8 Antibody (PACO59189)
- SKU:
- PACO59189
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CPNE8 Antibody (PACO59189) |
| Antibody SKU: | PACO59189 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Copine-8 protein (349-498AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59189 diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO59189 diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. |
| Synonyms: | Copine-8 (Copine VIII), CPNE8 |
| UniProt Protein Function: | CPNE8: a member of the copine protein family with calcium-dependent phospholipid binding properties. Copines are ubiquitously expressed, phospholipid-binding proteins that have been conserved through evolution. Highest expression of CPNE8 mRNA is seen in the prostate, heart, and brain. Fusion to AML1 in a t(12;21) translocation causes aggressive acute myelogenous leukemia. Two alternatively spliced isoforms have been described.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q12 |
| UniProt Protein Details: | |
| NCBI Summary: | Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86YQ8 |
| NCBI GenInfo Identifier: | 115502379 |
| NCBI Gene ID: | 144402 |
| NCBI Accession: | Q86YQ8.2 |
| UniProt Secondary Accession: | Q86YQ8,Q2TB41, Q86VY2 |
| UniProt Related Accession: | Q86YQ8 |
| Molecular Weight: | 25,664 Da |
| NCBI Full Name: | Copine-8 |
| NCBI Synonym Full Names: | copine 8 |
| NCBI Official Symbol: | CPNE8 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | copine-8 |
| UniProt Protein Name: | Copine-8 |
| UniProt Synonym Protein Names: | Copine VIII |
| Protein Family: | Copine |
| UniProt Gene Name: | CPNE8 |
| UniProt Entry Name: | CPNE8_HUMAN |
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