COX18 Antibody (PACO17717)
- SKU:
- PACO17717
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | COX18 Antibody (PACO17717) |
| Antibody SKU: | PACO17717 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human COX18 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17717(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17717(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain. |
| Synonyms: | COX18 cytochrome C oxidase assembly factor |
| UniProt Protein Function: | COX18: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4q13.3Cellular Component: integral to mitochondrial inner membraneMolecular Function: protein transporter activityBiological Process: protein transport; protein insertion into mitochondrial membrane; respiratory chain complex IV assembly |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q8N8Q8 |
| NCBI GenInfo Identifier: | 38372495 |
| NCBI Gene ID: | 285521 |
| NCBI Accession: | Q8N8Q8.1 |
| UniProt Secondary Accession: | Q8N8Q8,Q2PB66, Q2PB67, Q2PB68, Q49B97, Q6IPP9 |
| UniProt Related Accession: | Q8N8Q8 |
| Molecular Weight: | 333 |
| NCBI Full Name: | Mitochondrial inner membrane protein COX18 |
| NCBI Synonym Full Names: | COX18 cytochrome c oxidase assembly factor |
| NCBI Official Symbol: | COX18 |
| NCBI Official Synonym Symbols: | COX18HS |
| NCBI Protein Information: | mitochondrial inner membrane protein COX18; cytochrome c oxidase assembly homolog 18; cytochrome c oxidase assembly protein 18 |
| UniProt Protein Name: | Mitochondrial inner membrane protein COX18 |
| UniProt Synonym Protein Names: | Cytochrome c oxidase assembly protein 18 |
| Protein Family: | Mitochondrial inner membrane protein |
| UniProt Gene Name: | COX18 |
| UniProt Entry Name: | COX18_HUMAN |
| Antibodies |
| COX18 Antibody (PACO08545) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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