COX17 Antibody (PACO23780)
- SKU:
- PACO23780
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | COX17 Antibody (PACO23780) |
| Antibody SKU: | PACO23780 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from N-terminal of human COX17. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using COX17 antibody. |
 | Western blot analysis of extracts from 3T3 cells (Lane 2), using COX17 antiobdy. The lane on the left is treated with synthesized peptide. |
 | Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO cells and 293 cells, using COX17 antibody. |
| Background: | Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX By similarity. |
| Synonyms: | Cytochrome c oxidase copper chaperone; COX17; |
| UniProt Protein Function: | COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylationChromosomal Location of Human Ortholog: 3q13.33Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane spaceMolecular Function: copper ion binding; copper chaperone activityBiological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14061 |
| NCBI GenInfo Identifier: | 5031645 |
| NCBI Gene ID: | 10063 |
| NCBI Accession: | NP_005685 |
| UniProt Secondary Accession: | Q14061 |
| UniProt Related Accession: | Q14061 |
| Molecular Weight: | |
| NCBI Full Name: | cytochrome c oxidase copper chaperone isoform b |
| NCBI Synonym Full Names: | cytochrome c oxidase copper chaperone COX17 |
| NCBI Official Symbol: | COX17 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cytochrome c oxidase copper chaperone |
| UniProt Protein Name: | Cytochrome c oxidase copper chaperone |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cytochrome c oxidase copper chaperone |
| UniProt Gene Name: | COX17 |
| UniProt Entry Name: | COX17_HUMAN |
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